Flucytosine
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Flucytosine Definition
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
Flucytosine Synonyms
Flucytosine, 4-Amino-5-fluoro-2(1H)-pyrimidinone, 5-FC, 5-Fluorocytosine, Alcobon, Ancobon, Ancotil, FLUCYTOSINE, Ro 2-9915, Ro-2-9915, flucytosine
Terms in Flucytosine category
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