Forkhead Box Protein-O4 Protein
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Forkhead Box Protein-O4 Protein Definition
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas by human MLLT7 Gene (Forkhead Family), 505-aa 54-kDa Forkhead Box Protein O4 is highly similar to forkhead transcription factor FKHR protein within its single forkhead domain and contains serine- and proline-rich regions like ENL protein. AFX-like proteins appear involved in cell cycle regulation. MLLT7 appears to block cell cycle progression at G1, independent of Rb but dependent on p27(KIP1). MLLT7 transcriptionally activates p27(KIP1). MLLT7 may also play a role in the insulin signaling pathway. Acute leukemia chromosomal translocation t(X;11)(q13;q23) involves MLLT7 fused to MLL/HRX that encodes a chimeric rogue activator protein. (NCI)
Forkhead Box Protein-O4 Protein Synonyms
Forkhead Box Protein O4, AFX, AFX1, FOXO4, Fork Head Domain Transcription Factor AFX1, MLLT7, Trithorax Homolog 7
Terms in Forkhead Box Protein-O4 Protein category
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