Cancer Terms

Fotemustine

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Nitrosourea Compound -> Fotemustine

Fotemustine Definition

A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.

Fotemustine Synonyms

Fotemustine, 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester, Muphoran, S 10036, [1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester, diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate

Terms in Fotemustine category



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