Cancer Terms

Frizzled-7 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> G Protein-Coupled Receptor -> Frizzled-7 Protein

Frizzled-7 Protein Definition

Frizzled 7, encoded by the human FZD7 gene, is a G protein-coupled receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression downregulates APC function and enhances beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. (From LocusLink and NCI)

Frizzled-7 Protein Synonyms

Frizzled 7, FZD7, FZD7 Protein, FZE3, Frizzled Homolog 7 (Drosophila), Frizzled, Drosophila, Homolog of, 7, Frizzled-7, Fz-7, hFz7

Terms in Frizzled-7 Protein category



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