Cancer Terms

Furosemide

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Blood And Body Fluid -> Diuretic -> Loop Diuretic -> Furosemide

Furosemide Definition

An anthranilic derivative and loop diuretic with antihypertensive effect. Furosemide blocks the Na-K-Cl cotransporter (NKCC) in the luminal membrane of the thick ascending limb of the loop of Henle in the kidney, by binding to the Cl-binding site located in the cotransporter's transmembrane domain, thereby inhibiting reabsorption of sodium, chloride, potassium ions and water. This agent reduces plasma and extracellular fluid volume resulting in decreased blood pressure and cardiac output.

Furosemide Synonyms

Furosemide, FRS, FUROSEMIDE, LB 502, LB-502, Lasix, SK-Furosemide

Terms in Furosemide category



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