Cancer Terms

G Protein-Coupled Receptor Kinase-2-Like Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> G Protein-Coupled Receptor Kinase Family -> G Protein-Coupled Receptor Kinase-2-Like Protein

G Protein-Coupled Receptor Kinase-2-Like Protein Definition

Expressed primarily in testis and brain by human GPRK2L Gene (GPRK Family), one of 4 alternative isoforms (GRK4A, B, C, D) of 578-/546-/532-aa 67-kDa G Protein-Coupled Receptor Kinase 2-Like is a Ser/Thr kinase containing an RGS domain that phosphorylates activated GPCRs and may play a role in receptor desensitization. Only full-length GRK4D has kinase activity, can phosphorylate rhodopsin, and is inhibited by calmodulin. The other isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. (NCI)

G Protein-Coupled Receptor Kinase-2-Like Protein Synonyms

G Protein-Coupled Receptor Kinase 2-Like, EC 2.7.1.-, G Protein-Coupled Receptor Kinase 2 (Drosophila)-Like, G Protein-Coupled Receptor Kinase GRK4, G Protein-Dependent Receptor Kinase 4, GPRK2L, ITI1

Terms in G Protein-Coupled Receptor Kinase-2-Like Protein category



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