G Protein-Coupled Receptor-68

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> G Protein-Coupled Receptor -> G Protein-Coupled Receptor-68

G Protein-Coupled Receptor-68 Definition

Expressed in spleen, testis, peripheral leukocytes, brain, lung, and placenta by GPR68 Gene (GPCR1 Family), 365-aa 41-kDa 7-transmembrane G Protein-Coupled Receptor 68 is a high affinity receptor for sphingosylphosphorylcholine that acts as a proton-sensing receptor and stimulates PI hydrolysis. The receptor is inactive at pH 7.8 and fully activated at pH 6.8; extracellular histidines are involved in pH sensing. (NCI)

G Protein-Coupled Receptor-68 Synonyms

G Protein-Coupled Receptor 68, GPR68, OGR-1, Ovarian Cancer G Protein-Coupled Receptor 1, Sphingosylphosphorylcholine Receptor

Terms in G Protein-Coupled Receptor-68 category

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