GATA-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> DNA Binding Protein -> Sequence-Specific DNA Binding Protein -> GATA-Binding Protein -> GATA-1

GATA-1 Definition

Encoded by human GATA1 Gene (GATA Family), 413-aa 42.8-kD tissue-specific transcriptional activator GATA-1, a general switch factor for erythroid/megakaryocyte development, contains a conserved central domain of 2 GATA/C4 zinc fingers that recognize the WGATAR motif. The fingers cooperate in specific binding of the consensus DNA sequence (A/T)GATA(A/G) in erythroid genes. The N-finger interacts with zinc finger FOG1 protein, also essential for erythroid/megakaryocyte development. V205M abrogates GATA1 N-finger interaction with FOG. Regulatory feedback by death-receptor ligands results in caspase-mediated GATA1 degradation and impaired erythroblast development. Arg216gly substitution in the GATA1 N-finger causes X-linked thrombocytopenia; reduces GATA1/FOG1 affinity for palindromic GATA sites. (from LocusLink, Swiss-Prot, OMIM, and NCI)

GATA-1 Synonyms

GATA-1, ERYF1, Erythroid Transcription Factor, Erythrold Transcription Factor 1, GATA Binding Protein 1, GATA1, GF1, Globin Transcription Factor 1, NFE1, Transcription Factor GATA1

GATA-1

GATA-1 Definition

GATA-1 Synonyms

Terms in GATA-1 category