GPCR Signaling Pathway
Cancer Terms ->
Biochemical Pathway ->
Signaling Pathways -> GPCR Signaling Pathway
GPCR Signaling Pathway Definition
The binding of b-arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Src-TK), to the receptor-b-arrestin complex. Several signaling events have been reported to involve b-arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent beta2-adrenergic receptor endocytosis by tyrosine phosphorylation of dynamin, Ras-dependent activation of the ERK1/2 MAP kinase cascade and stimulation of cell proliferation by beta2-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation. (Biocarta)
GPCR Signaling Pathway Synonyms
GPCR Signaling Pathway, Roles of beta-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling
Terms in GPCR Signaling Pathway category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.