Gene Rearrangement

Cancer Terms -> Biological Process -> Subcellular Process -> Biochemical Process -> Molecular Sequence Alteration -> DNA Sequence Alteration -> DNA Sequence Rearrangement -> Gene Rearrangement

Gene Rearrangement Definition

Covalent DNA changes in cells during normal differentiation resulting in new sequences, expression, or gene products; this is a mechanism of binding site diversification for antibodies, certain receptors, and possibly other proteins. The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development. This includes the ordered rearrangement of variable gene regions; especially, the rearrangement of antibody genes during the differentiation of B-lymphocytes and the rearrangement of T-cell antigen receptor genes.

Gene Rearrangement Synonyms

Gene Rearrangement

Terms in Gene Rearrangement category

Immunoglobulin Gene Rearrangement