General Transcription Factor-IIIC5-63kDa

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Basal Transcription Factor -> General Transcription Factor-IIIC5-63kDa

General Transcription Factor-IIIC5-63kDa Definition

Encoded by human GTF3C5 Gene, General Transcription Factor IIIC5 63kDa is a subunit of general transcription factor GTF3C, a component of RNA polymerase III and essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA. To initiate RNA synthesis, RNA polymerases need GTFs to assemble in a promoter-bound complex and recruit RNA polymerase. GTF3C complex interacts with GTF3B in recruiting RNA polymerase III. GTF3C5 contains a central helix-turn-helix motif and a C-terminal acidic region. (NCI)

General Transcription Factor-IIIC5-63kDa Synonyms

General Transcription Factor IIIC5 63kDa, GTF3C5, TFIIIC Epsilon, TFIIIC63, Transcription Factor IIIC 63 kD

Terms in General Transcription Factor-IIIC5-63kDa category

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