General Transcription Factor-TFIIB

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Basal Transcription Factor -> General Transcription Factor-TFIIB

General Transcription Factor-TFIIB Definition

Encoded by human TFIIB Gene, ubiquitous nuclear General Transcription Factor TFIIB plays a central role in assembly of the preinitiation complex, required for transcription initiation by RNA polymerase II. Sequence-specific DNA-binding TFIIB forms the DAB complex with promoter-bound TFIID and TFIIA, bridging TFIID and RNA Polymerase II. TFIIB interacts with the promoter TFIIB-recognition element BRE. BRE suppresses basal transcription by a core promoter, which increases transcription in the presence of an activator that can disrupt promoter-bound TFIIB-BRE. (NCI)

General Transcription Factor-TFIIB Synonyms

General Transcription Factor TFIIB, GTF2B, General Transcription Factor IIB, RNA Polymerase II Transcription Factor IIB, S300-II, Transcription Initiation Factor IIB

Terms in General Transcription Factor-TFIIB category

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