Cancer Terms

Glucose Phosphate Isomerase

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Glucose Phosphate Isomerase Definition

Encoded by human GPI Gene (GPI Family), Glucose-6-Phosphate Isomerase, Neuroleukin, and Autocrine Motility Factor function in different capacities. In glycolysis and gluconeogenesis, homodimeric cytoplasmic GPI catalyzes reversible G6P and F6P isomerization. Produced by lectin-stimulated T-cells, secreted non-mitogenic NLK lymphokine acts early in antibody-secreting cell formation to induce Ig secretion. Also a neurotrophic factor for spinal and sensory neurons, NLK exhibits GPI activity. AMF is a 558-amino acid 55-kD autocrine motility polypeptide. The gene product is partly homologous to a conserved region of HTLV-III-LAV external envelope protein. Gene defects cause nonspherocytic hemolytic anemia and hydrops fetalis. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Glucose Phosphate Isomerase Synonyms

Glucose Phosphate Isomerase, AMF, Autocrine Motility Factor, D-Glucose-6-Phosphate Ketol-Isomerase, EC 5.3.1.9, GPI, Glucosephosphate Isomerase, Hexose Monophosphate Isomerase, Hexosephosphate Isomerase, Neuroleukin, Oxoisomerase, Phosphoglucose Isomerase, Phosphohexomutase, Phosphohexose Isomerase, Phosphosaccharomutase, SA-36, Sperm Antigen-36

Terms in Glucose Phosphate Isomerase category



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