Cancer Terms

Glutamic-Pyruvate Transaminase-2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Transaminase -> SGPT-ALT Protein -> Glutamic-Pyruvate Transaminase-2

Glutamic-Pyruvate Transaminase-2 Definition

Expressed in muscle, fat, kidney, brain, liver, and breast by human GPT2 Gene (Alanine Aminotransferase Family), 523-aa 58-kDa Glutamic-Pyruvate Transaminase 2 is a mitochondrial pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and gluconeogenesis. Sharing 69% identity with GPT, GPT2 contains a complete transaminase class I domain and a partial transaminase class II domain. GPT2 mediates conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI)

Glutamic-Pyruvate Transaminase-2 Synonyms

Glutamic-Pyruvate Transaminase 2, ALT2, Alanine Aminotransferase 2, GPT2

Terms in Glutamic-Pyruvate Transaminase-2 category



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