Glutaminase
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Glutaminase Definition
Encoded by human GA Gene, the 602-amino acid 66 kD (precursor) Glutaminase (GA Family) has a putative N-terminal mitochondrial import presequence. Expressed in liver, brain, and pancreas, but not in kidney, heart, skeletal muscle, lung, or placenta, GA protein shares 94% and 72% sequence identity with rat liver and kidney glutaminases, respectively. Containing two ankyrin repeats, human glutaminase is most similar to rat liver-type glutaminase, but is not liver specific. Involved in regulation of glutamine catabolism, mitochondrial glutaminase converts L-glutamine to L-glutamate and NH3. Glutaminase expression and activity depend on the cell proliferation state with highest levels at the beginning of the exponential growth phase. (NCI)
Glutaminase Synonyms
Glutaminase, Breast Cell Glutaminase, EC 3.5.1.2, GA, GA Protein, GLS2, Liver Glutaminase
Terms in Glutaminase category
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