Glyburide
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Glyburide Definition
A member of the second generation of the sulfonylurea hypoglycemic agents. Glyburide inhibits the ATP-sensitive potassium channels on the beta-cell membrane, thereby preventing potassium efflux leading to membrane depolarization and subsequent calcium influx. The increased intracellular levels of calcium induce insulin secretion from functioning beta-cells of the pancreatic islet tissue and leads to a lowering in blood glucose levels.
Glyburide Synonyms
Glyburide, GLYBURIDE, Glibenclamide, Micronase
Terms in Glyburide category
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