Growth Differentiation Factor-8

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Growth Factor -> Transforming Growth Factor -> Transforming Growth Factor-Beta -> Bone Morphogenetic Protein -> Growth Differentiation Factor-8

Growth Differentiation Factor-8 Definition

Growth Differentiation Factor 8, encoded by the human GDF8 gene, is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in the control and maintenance of skeletal muscle mass. It acts specifically as a negative regulator of skeletal muscle growth by signaling through receptor serine/threonine kinases. This protein is synthesized as a preprotein activated by 2 proteolytic cleavages. Removal of the signal sequence is followed by cleavage at a tetrabasic processing site, resulting in a 26-kD amino-terminal propeptide and a 12.5-kD carboxy-terminal peptide, a dimer of which is the biologically active portion of the protein. (From LocusLink, OMIM and NCI)

Growth Differentiation Factor-8 Synonyms

Growth Differentiation Factor 8, GDF8, GDF8 Protein

Growth Differentiation Factor-8

Growth Differentiation Factor-8 Definition

Growth Differentiation Factor-8 Synonyms

Terms in Growth Differentiation Factor-8 category