HL-60 MX1

Cancer Terms -> NCI Administrative Concepts -> Cancer Science -> Specimen -> Cell Line -> Human Cell Line -> Tumor Cell Line -> HL-60 MX1

HL-60 MX1 Definition

HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.

HL-60 MX1 Synonyms

HL-60/MX1

HL-60 MX1

HL-60 MX1 Definition

HL-60 MX1 Synonyms

Terms in HL-60 MX1 category