HMGB1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> DNA Binding Protein -> Canonical HMG Protein -> HMGB Family Protein -> HMGB1

HMGB1 Definition

HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221)

HMGB1 Synonyms

HMGB1, Amphoterin, Chromosomal Protein, Nonhistone, HMG1, HMG 1, HMG-1, HMG1, HMG3, High Mobility Group Protein 1, High-Mobility Group (Nonhistone Chromosomal) Protein 1, High-Mobility Group Box 1, Nonhistone Chromosomal Protein HGM1, SBP-1, Sulfoglucuronyl Carbohydrate Binding Protein

HMGB1

HMGB1 Definition

HMGB1 Synonyms

Terms in HMGB1 category