HMGB2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> DNA Binding Protein -> Canonical HMG Protein -> HMGB Family Protein -> HMGB2

HMGB2 Definition

HMGB2 contains two DNA-binding HMG-box domains (A and B) and a long acidic C-terminal domain. It binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. The individual A and B boxes (which, although broadly similar, show both structural and functional differences) exhibit many of the structure-specific properties of the whole protein. The acidic tail modulates the affinity of the tandem HMG boxes in HMG2 for a variety of DNA targets, including four-way junctions, but not distorted DNA minicircles, to which the proteins bind with very high affinity. HMGB2 appears to play important architectural roles in the assembly of nucleoprotein complexes in a variety of biological processes, for example V(D)J recombination, the initiation of transcription, and DNA repair. (Biochem Soc Trans 2001 Aug;29(Pt 4):395-401)

HMGB2 Synonyms

HMGB2, Chromosomal Protein, Nonhistone, HMG2, HMG 2, HMG-2, HMG2, HMGB2 Protein, High Mobility Group Box 2, High Mobility Group Protein 2, High-Mobility Group (Nonhistone Chromosomal) Protein 2, High-Mobility Group Box 2, Nonhistone Chromosomal Protein HMG2

HMGB2

HMGB2 Definition

HMGB2 Synonyms

Terms in HMGB2 category