HMGN1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> DNA Binding Protein -> Canonical HMG Protein -> HMGN Family Protein -> HMGN1

HMGN1 Definition

HMGN1 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN1 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995 Aug;6(4):247-55)

HMGN1 Synonyms

HMGN1, Chromosomal Protein, Nonhistone, HMG14, HMG 14, HMG-14, HMG14, HMGN1 Protein, High Mobility Group Nucleosomal Binding Protein 1, High Mobility Group Protein 14, High-Mobility Group (Nonhistone Chromosomal) Protein 14, High-Mobility Group Nucleosome Binding 1, High-Mobility Group Nucleosome Binding Domain 1, Human Non-Histone Chromosomal Protein HMG-14, Nonhistone Chromosomal Protein HMG-14, Nonhistone Chromosomal Protein HMG14

HMGN1

HMGN1 Definition

HMGN1 Synonyms

Terms in HMGN1 category