HMGN2 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> DNA Binding Protein -> Canonical HMG Protein -> HMGN Family Protein -> HMGN2 Protein

HMGN2 Protein Definition

HMGN2 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN2 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995 Aug;6(4):247-55)

HMGN2 Protein Synonyms

HMGN2 Protein, Chromosomal Protein, Nonhistone, HMG17, HMG-17, HMG17, HMGN2, High Mobility Group Nucleosomal Binding Protein 2, High Mobility Group Protein 17, High Mobility Group Protein N2, High-Mobility Group (Nonhistone Chromosomal) Protein 17, High-Mobility Group Nucleosomal Binding Domain, High-Mobility Group Nucleosomal Binding Domain 2, High-Mobility Group Nucleosome Binding Domain 2, MGC5629, Nonhistone Chromosomal Protein HMG-17, Nonhistone Chromosomal Protein HMG1, Nonhistone Chromosomal Protein HMG17

HMGN2 Protein

HMGN2 Protein Definition

HMGN2 Protein Synonyms

Terms in HMGN2 Protein category