Halofuginone Hydrobromide
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Halofuginone Hydrobromide Definition
The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.
Halofuginone Hydrobromide Synonyms
Halofuginone Hydrobromide, HALOFUGINONE HYDROBROMIDE, Halofuginone IV (intravenous), Halofuginone hydrobromide, RU 19110, Tempostatin, halofuginone hydrobromide
Terms in Halofuginone Hydrobromide category
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