Helicase-SKI2W
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Enzyme ->
Hydrolase ->
Helicase ->
RNA Helicase -> Helicase-SKI2W
Helicase-SKI2W Definition
Encoded by human SKIV2L Gene (SKI2 Helicase Family), 1246-aa 138-kDa Helicase SKI2W is a conserved DEAD box protein yeast SKI2 homologue containing a leucine zipper domain, motifs associated with RNA helicases, and ATPase activity that may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. Conserved motif DEAD box RNA helicases are implicated in translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Rapid 3-prime-to-5-prime degradation of unstable mammalian mRNAs containing 3-prime UTR AU-rich elements (AREs) is mediated by the multisubunit exosome. ARE-binding proteins interact with the exosome and recruit it to ARE-containing RNAs, promoting their degradation. Helicase SKI2W is an exosome-associated factor. (NCI)
Helicase-SKI2W Synonyms
Helicase SKI2W, HLP, Helicase-Like Protein, SKIV2L, Superkiller Viralicidic Activity 2-Like Homolog
Terms in Helicase-SKI2W category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.