Helix-Turn-Helix Motif

Cancer Terms -> Anatomic Structure System or Substance -> Microanatomy -> Macromolecular Structure -> Protein Structure -> Protein Domain -> Ligand Binding Domain -> DNA Binding Domain -> Helix-Turn-Helix Motif

Helix-Turn-Helix Motif Definition

The first DNA-binding protein motif to be recognized. Originally identified in bacterial proteins and found in many DNA-binding proteins from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices.

Helix-Turn-Helix Motif Synonyms

Helix-Turn-Helix Motif, HTH DNA Binding Domain, Helix-Turn-Helix

Terms in Helix-Turn-Helix Motif category

HT-Zip Domain
Homeo Domain
POU Domain
Winged Helix