Heparin Binding Growth Factor

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Growth Factor -> Heparin Binding Growth Factor

Heparin Binding Growth Factor Definition

Exhibiting high affinity for heparin, Heparin-Binding Growth Factors (HBGF) control proliferation and differentiation of mesenchymal, epithelial, and neuroectodermal cells. Heparin may store some growth factors in the extracellular matrix, stabilize these proteins, and protect them. For some factors, heparin binding is essential to interact with receptors; it enhances the activity of some HBGF. Class 1 factors comprise acidic proteins, related to (acidic) aFGF. Class 2 factors comprise basic proteins, related to (basic) bFGF. HBGFs appear to be products of different genes; some may not be mitogenic or secreted. Current members include FGF-1, FGF-2, FGF-3, FGF-4, FGF-5, FGF-6, FGF-7, FGF-8, FGF-9, FGF-10, FGF-11, FGF-12, FGF-13, FGF-14, FGF-15, FGF-16, FGF-17, FGF-18, FGF-19, FGF-20, FGF-21, FGF-22, and FGF-23. (NCI)

Heparin Binding Growth Factor Synonyms

Terms in Heparin Binding Growth Factor category

Fibroblast Growth Factor