Histone Deacetylase-3
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Histone Deacetylase-3 Definition
Histone deacetylase 3 is one of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p. Two isoforms are produced by alternative splicing and it appears to be expressed ubiquitously. HDAC3 can be found in complexes that include HDAC4 and HDAC5, deacetylases with similarity to yeast Hda1 deacetylase. HDAC3 may regulate transcription through binding the zinc-finger transcription factor YY1, increasing its repression activity. RELA is a nonhistone substrate of HDAC3. IKBA-dependent nuclear export of deacetylated RELA replenishes the cytoplasmic pool of NFKB/IKBA complexes for NFKB responses. (from OMIM 605166 and NCI)
Histone Deacetylase-3 Synonyms
Histone Deacetylase 3, HDAC3
Terms in Histone Deacetylase-3 category
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