Histone Deacetylase-4
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Histone Deacetylase-4 Definition
Histone deacetylase 4 is one of three identified histone deacetylases with similarity to the yeast Hda1 histone deacetylase. It is expressed differentially in brain, heart, and skeletal muscle and is found in complexes with HDAC3 and HDAC5. HDAC4 possesses deacetylation activity with all four core histones. HDAC4 interacts with multiple proteins. HDAC4 does not bind DNA directly, but rather through MEF2C and MEF2D. Binding of HDAC4 to MEF2C represses MEF2C transcription activity. (from OMIM 605314 and NCI)
Histone Deacetylase-4 Synonyms
Histone Deacetylase 4, HDAC-A, HDAC4, Histone Deacetylase A
Terms in Histone Deacetylase-4 category
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