Histone Deacetylase-5
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Histone Deacetylase-5 Definition
Histone deacetylase 5 is one of three identified histone deacetylases with similarity to the yeast Hda1 histone deacetylase. It is expressed differentially, is found in complexes with HDAC4 and HDAC3, and possesses deacetylation activity with all four core histones. MEF2A transcription factors interact with HDAC4 and HDAC5, resulting in repression of MEF2-dependent genes. Muscle differentiation requires release of MEF2 from repression by HDACs. HDAC5 shuttles from nucleus to cytoplasm when myoblasts are triggered to differentiate. CAMK1 signaling prevents formation of MEF2/HDAC complexes and induces nuclear export of HDAC4 and HDAC5 by phosphorylation.
Histone Deacetylase-5 Synonyms
Histone Deacetylase 5, HDAC5
Terms in Histone Deacetylase-5 category
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