Histone-H2AX

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Structural Protein -> Histone -> Histone-H2A -> Histone-H2AX

Histone-H2AX Definition

Encoded by human H2AX Gene (H2A Family) and expressed unlinked to replication in G1 and S-phase, 142-aa basal Histone H2AX has a unique conserved C-terminal sequence, QASQEY. NBS1/phospho-H2AX (gamma-H2AX) associate with irradiation-induced and V(D)J-induced DNA double-strand breaks. In pre-thymocytes, NBS1/gamma-H2AX form at RAG1-mediated TCRA V(D)J cleavage sites. NBS1/gamma-H2AX facilitate AID-dependent DNA break repair in G1 cells undergoing Ig heavy-chain constant region class switch recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Histone-H2AX Synonyms

Histone H2AX, H2A Histone Family, Member X, H2A.X, H2A/X, H2AFX, H2AX, H2AX Histone, Histone H2A.X

Terms in Histone-H2AX category

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