Homeobox Protein-A9
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Homeobox Protein-A9 Definition
Encoded by human HOXA9 Gene (ABD-B Family), 272-amino acid 30-kD Homeobox Protein A9 isoforms are class I sequence-specific DNA-binding homeobox transcription factors potentially involved in morphogenesis and myeloid differentiation; expression is spatially and temporally regulated during embryonic development. Frameshifted isoform B contains a distinct C-terminus lacking the homeodomain. HOXA9 acts within a developmental regulatory system that provides specific anterior-posterior positional identity to cells. Associated with acute myeloid leukemogenesis, a chimerically fused in-frame nucleoporin NUP98 amino terminal half to HOXA9 may inhibit differentiation or disrupt nucleocytoplasmic transport. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Homeobox Protein-A9 Synonyms
Homeobox Protein Hox-A9, ABD-B, HOX1.7, HOX1G, HOXA9, HOXA9 Protein, Homeobox Protein 1G, Homeobox Protein A9, Homeobox Protein HOXA9, Homeodomain Protein HOXA9, Hox-1G
Terms in Homeobox Protein-A9 category
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