Hsp90 Inhibitor SNX-5542 Mesylate
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Heat Shock Protein Inhibitor -> Hsp90 Inhibitor SNX-5542 Mesylate
Hsp90 Inhibitor SNX-5542 Mesylate Definition
The orally bioavailable mesylate salt of a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted to SNX-2112, which accumulates in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses.
Hsp90 Inhibitor SNX-5542 Mesylate Synonyms
Hsp90 Inhibitor SNX-5542 Mesylate, SNX-5422 Mesylate
Terms in Hsp90 Inhibitor SNX-5542 Mesylate category
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