Cancer Terms

HuCC49deltaCH2-PA-DOTA

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Response Modifier -> Immunoconjugate -> Conjugated Mononclonal Antibody CC49 -> HuCC49deltaCH2-PA-DOTA

HuCC49deltaCH2-PA-DOTA Definition

An immunoconjugate comprised of a humanized monoclonal antibody with antitumor activity. The monoclonal antibody CC49 is developed from the murine monoclonal antibody B72.3 and is humanized by grafting the hypervariable regions onto the variable light (VL) and variable heavy (VH) frameworks of the monoclonal antibodies LEN and 21/28' CL. In addition the CH2 domain in the constant region is deleted to increase plasma clearance. The resultant antibody binds to the pancarcinoma tumor-associated glycoprotein (TAG)-72 with high affinity. Furthermore, the antibody is conjugated to PA-DOTA, a bifunctional chelating agent and commonly radiolabeled, resulting in an effective agent for radioimmunotherapy.

HuCC49deltaCH2-PA-DOTA Synonyms

HuCC49deltaCH2-PA-DOTA, HuCC49DCH2-PA-DOTA

Terms in HuCC49deltaCH2-PA-DOTA category



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