Human Anti-Alpha-5 Integrin Monoclonal Antibody

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Human Anti-Alpha-5 Integrin Monoclonal Antibody Definition

A pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and alpha-v beta-6 integrins with antiangiogenic and antitumor activities. Human anti-alpha-v integrin monoclonal antibody competitively binds to and blocks both alpha-v beta-3 and alpha-v beta-5 integrins, resulting in inhibition of integrin-mediated tumor angiogenesis and tumor growth. Integrins facilitate the adhesion of stimulated endothelial cells to the extracellular matrix (ECM); trigger the secretion of ECM-rearranging proteases; and propagate signaling events that promote the survival and differentiation of cells in newly formed vasculature.

Human Anti-Alpha-5 Integrin Monoclonal Antibody Synonyms

Intetumumab, CNTO 095, CNTO-95, Human Anti-Alpha-5 Integrin Monoclonal Antibody, INTETUMUMAB, Immunoglobulin G1, anti-(human integrin alpha-V (vitronectin receptor subunit alpha or CD51); human monoclonal CNTO 95 gama1 heavy chain (222-215')-disulfide with human monoclonal CNTO 95 kappa light chain dimer (228-228'':231-231'')-bisdisulfide

Terms in Human Anti-Alpha-5 Integrin Monoclonal Antibody category

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