Hydroxysteroid-17-Beta Dehydrogenase-2
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Hydroxysteroid-17-Beta Dehydrogenase-2 Definition
Expressed in many peripheral tissues (high in placenta) by human HSD17B2 Gene (SDR Family), 387-aa 43-kDa Hydroxysteroid 17-Beta Dehydrogenase 2 is a potential type II membrane protein enzyme with an N-terminal type II signal-anchor motif and a C-terminal ER retention motif, likely associated with ER membranes, that uses NADH in the oxidative inactivation metabolism of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 also has 3-beta-HSD activity and 20-alpha-HSD activity toward 20-alpha-dihydroprogesterone. (NCI)
Hydroxysteroid-17-Beta Dehydrogenase-2 Synonyms
Hydroxysteroid 17-Beta Dehydrogenase 2, 17-Beta Hydroxysteroid Dehydrogenase, 17-Beta-HSD, EC 1.1.1.62, Estradiol 17 Beta-Dehydrogenase, HSD17B2
Terms in Hydroxysteroid-17-Beta Dehydrogenase-2 category
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