Cancer Terms

Hydroxysteroid-17-Beta Dehydrogenase-7

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Oxidoreductase -> Hydroxysteroid-17-Beta Dehydrogenase-7

Hydroxysteroid-17-Beta Dehydrogenase-7 Definition

Encoded by human HSD17B7 Gene (SDR Family) and expressed in breast, ovaries, pregnant uterus, placenta, testis, thymus, prostate, fetal liver, and some neural tissues, 341-amino acid 38-kD 17-Beta-Hydroxysteroid Dehydrogenase 7 oxidizes or reduces estrogens and androgens. Responsible for biosynthesis of estradiol in the corpus luteum during pregnancy, the membrane-associated phosphorylated enzyme is nearly 75% identical to rodent proteins and contains a short chain dehydrogenase domain. Close to the transmembrane domain, HSD17B7 contains a 28-residue superficial loop: a candidate prolactin receptor (PRLR)-binding domain. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Hydroxysteroid-17-Beta Dehydrogenase-7 Synonyms

17-Beta-Hydroxysteroid Dehydrogenase 7, 17 Beta-Hydroxysteroid Dehydrogenase Type 7, 17 Beta-Hydroxysteroid Dehydrogenase Type VII, 17-Beta-HSD 7, EC 1.1.1.51, Estradiol 17 Beta-Dehydrogenase 7, HSD17B7, Hydroxysteroid (17-Beta) Dehydrogenase 7

Terms in Hydroxysteroid-17-Beta Dehydrogenase-7 category



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