I-Kappa-B Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> I-Kappa-B Protein

I-Kappa-B Protein Definition

Interacting with p65 (RELA), widely expressed 36-38kDa unphosphorylated cytoplasmic ANK-repeat human I Kappa B Proteins A/B/E (NFKBI Family) inhibit NF-Kappa-B, trapping it in the cytoplasm. By complexing with NFKB, IKBs regulate NFKB transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Cytokine-activated serine phosphorylation of IKBs by IKBKA/IKBKB disables the NFKB inhibition by dissociation; promotes polyubiquitinated proteasome-dependent IKB degradation; and allows NFKB nuclear translocation, binding at kappa-B DNA motifs, and target gene transcription. (NCI)

I-Kappa-B Protein Synonyms

I Kappa B, IKB, NF-Kappa B Inhibitor, NFKB Inhibitor, NFKBI

Terms in I-Kappa-B Protein category

I-Kappa-B-Alpha Protein
I-Kappa-B-Beta Protein
I-Kappa-B-Epsilon Protein