IGF1R Antagonist BMS-754807
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IGF1R Antagonist BMS-754807 Definition
An orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. IGF-1R antagonist BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways; inhibition of IGF-1R-mediated signaling pathways may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a receptor tyrosine kinase expressed on most tumor cells and is involved in mitogenesis, angiogenesis, and tumor cell survival.
IGF1R Antagonist BMS-754807 Synonyms
IGF1R Antagonist BMS-754807, BMS-754807
Terms in IGF1R Antagonist BMS-754807 category
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