IL12B wt Allele

Cancer Terms -> Gene -> Protein Complex Subunit Gene -> IL12B Gene -> IL12B wt Allele

IL12B wt Allele Definition

Human IL12B wild-type allele is located within 5q31.1-q33.1 and is approximately 16 kb in length. This allele, which encodes interleukin-12 beta chain protein, plays a role in promoting the growth of both T cells and natural killer cells. It is also involved in the differentiation of both Th1 and Th2 cells. Overexpression of the IL12B gene is associated with multiple sclerosis. A polymorphism in the promoter region of this gene is associated with the severity of both atopic and non-atopic asthma in children. Heritable defects in the IL12B gene are a cause of susceptibility to mycobacterial disease.

IL12B wt Allele Synonyms

IL12B wt Allele, CLMF, CLMF2, IL-12B, Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40) wt Allele, NKSF2

IL12B wt Allele

IL12B wt Allele Definition

IL12B wt Allele Synonyms

Terms in IL12B wt Allele category