INO-1001
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Poly ADP-Ribose Polymerase Inhibitor -> INO-1001
INO-1001 Definition
A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB).
INO-1001 Synonyms
INO-1001, INO 1001
Terms in INO-1001 category
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