ISIS 5132
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ISIS 5132 Definition
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI04)
ISIS 5132 Synonyms
ISIS 5132, CGP 69846A, CGP69846A, ISIS 5132/CGP69846A, ISIS-5132, RAF-IK Antisense ODN, c-RAF Antisense
Terms in ISIS 5132 category
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