IgG-Fc-Receptor-IIA

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Fc Receptor -> Fc-Gamma Receptor-II -> IgG-Fc-Receptor-IIA

IgG-Fc-Receptor-IIA Definition

Expressed in monocytes, macrophages, neutrophils, eosinophils, platelets, NK cells, and T- and B-lymphocytes by human FCGR2A Gene, 281-aa (mature) IgG Fc Receptor IIA is a type I cell surface membrane protein with 2 extracellular IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2A binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. An Arg167His polymorphism affects efficiency of IgG2 recognition. (NCI)

IgG-Fc-Receptor-IIA Synonyms

IgG Fc Receptor IIA, CD32, CD32 Antigen, FCG2, FCGR2, FCGR2A, FCGR2A1, Fc-Gamma RIIA, Fc-Gamma-RIIA, FcGR, FcRIIA, IGFR2, Low Affinity IgG Fc Fragment Receptor IIA, Low Affinity Immunoglobulin Gamma Fc Region Receptor IIA

IgG-Fc-Receptor-IIA

IgG-Fc-Receptor-IIA Definition

IgG-Fc-Receptor-IIA Synonyms

Terms in IgG-Fc-Receptor-IIA category