Cancer Terms

IgG-Fc-Receptor-IIC

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Fc Receptor -> Fc-Gamma Receptor-II -> IgG-Fc-Receptor-IIC

IgG-Fc-Receptor-IIC Definition

Expressed as 4 alternative isoforms in monocytes, macrophages, polymorphonuclear cells, and natural killer cells (Isoform 1) by human FCGR2C Gene, IgG Fc Receptor IIC is a type I cell surface protein with 2 IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2C binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2C contains two cytoplasmic ITAM activator motifs involved in cell activation upon receptor aggregation. Isoform 4 may be soluble. (NCI)

IgG-Fc-Receptor-IIC Synonyms

IgG Fc Receptor IIC, CD32, CD32 Antigen, FCGR2C, Fc-Gamma RIIC, Fc-Gamma-RIIC, FcRIIC, Low Affinity IgG Fc Fragment Receptor IIC, Low Affinity Immunoglobulin Gamma Fc Region Receptor IIC

Terms in IgG-Fc-Receptor-IIC category



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