Immunoglobulin Domain
Cancer Terms -> Anatomic Structure System or Substance -> Microanatomy -> Macromolecular Structure -> Protein Structure -> Protein Domain -> Immunoglobulin Domain
Immunoglobulin Domain Definition
The major histocompatibility complex (MHC) molecules are made of 2 chains, alpha and beta. In class I, the alpha chain is composed of 3 extracellular domains, a transmembrane region and a cytoplasmic tail while the beta chain is of a single extracellular domain. In class II, both the alpha and the beta chains are composed of 2 extracellular domains, a transmembrane region and a cytoplasmic tail. The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately one hundred amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions, e.g., antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. (InterPro IPR007110)Immunoglobulin Domain Synonyms
Immunoglobulin Domain, Immunoglobulin-Like DomainTerms in Immunoglobulin Domain category
Antibody Binding SiteFab Fragment
Immunoglobulin-Like C2-Type Domain
Immunoglobulin-Like V-Type Domain
Immunoglobulin Constant Region
Immunoglobulin Diversity Region
Immunoglobulin Fc
Immunoglobulin Hinge Region
Immunoglobulin Hypervariable Region
Immunoglobulin Joining Region
Immunoglobulin Variable Region