Immunoglobulin Gene Rearrangement
Cancer Terms -> Biological Process -> Subcellular Process -> Biochemical Process -> Molecular Sequence Alteration -> DNA Sequence Alteration -> DNA Sequence Rearrangement -> Gene Rearrangement -> Immunoglobulin Gene Rearrangement
Immunoglobulin Gene Rearrangement Definition
By translocation through a cascade of temporally ordered steps during B-cell development, Immunoglobulin Gene Rearrangement randomly joins discrete DNA segments that encode antibody variable-V, diversity-D, joining-J, and constant-C segments to complete the coding sequence for a single heavy or light chain gene. DNA recombinases recognize a palindromic heptamer and an AT-rich nonamer separated by a 12 or 23bp spacer recombination signal sequence (RSS) neighboring the coding regions; create double-stranded DNA breaks at the exon/RSS boundaries; excise intervening DNA; and ligate the DNA ends to create a contiguous reading frame.Immunoglobulin Gene Rearrangement Synonyms
Immunoglobulin Gene RearrangementTerms in Immunoglobulin Gene Rearrangement category
Generation of Antibody DiversityImmunoglobulin Switch Recombination
V-D-J Recombination