Immunoglobulin Kappa Locus
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Immunoglobulin Kappa Locus Definition
This region represents the germline organization of the kappa light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)
Immunoglobulin Kappa Locus Synonyms
Immunoglobulin Kappa Locus, IGK, Immunoglobulin Kappa Gene, Kappa Light Chain Gene
Terms in Immunoglobulin Kappa Locus category
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