Cancer Terms

Immunoglobulin Switch Recombination

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Immunoglobulin Switch Recombination Definition

B-lymphocytes can selectively switch to express different immunoglobulin (Ig) isotypes during the course of an immune response. Selective expression of an Ig isotype is regulated by a sequence-specific rearrangement process that replaces the first active set of Ig heavy-chain (IgH) constant-region exons with one of several other downstream constant-region (CH) genes.

Immunoglobulin Switch Recombination Synonyms

Immunoglobulin Switch Recombination, Immunoglobulin Isotype-Switch Recombination, Switch Recombination

Terms in Immunoglobulin Switch Recombination category



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