Cancer Terms

Indibulin

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Antimitotic Agent -> Tubulin Binding Agent -> Indibulin

Indibulin Definition

A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.

Indibulin Synonyms

Indibulin, D-24851, INDIBULIN, N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid), ZIO-301

Terms in Indibulin category



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