Insulin-Like Growth Factor-2 Receptor

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Insulin-Like Growth Factor-2 Receptor Definition

IGF2R is a 250kDa transmembrane protein. It was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via IGF2R either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of IGF2R molecules are located intracellularly, only 5-10% is present on the cell membrane. IGF2R is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta. It is a putative hepatocellular tumor suppressor. (from LocusLink)

Insulin-Like Growth Factor-2 Receptor Synonyms

Insulin-Like Growth Factor 2 Receptor, Cation-Independent Mannose-6 Phosphate Receptor, IGF2R

Terms in Insulin-Like Growth Factor-2 Receptor category

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