Cancer Terms

Intercellular Adhesion Molecule-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Cell Adhesion Molecule -> Intercellular Adhesion Molecule-3

Intercellular Adhesion Molecule-3 Definition

ICAM3 is a ligand for LFA-1, a major receptor of T-cells, B-cells, and granulocytes that mediates the leukocyte adhesion reactions underlying many immune functions. The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets. ICAM3 is potentially the most important ligand for LFA-1 in the initiation of the immune response. ICAM3 is closely related to ICAM1, consists of five Ig domains, and binds LFA-1 through its two N-terminal domains. (from OMIM 146631 and NCI)

Intercellular Adhesion Molecule-3 Synonyms

Intercellular Adhesion Molecule 3, CD50, CD50 Antigen, ICAM-3, ICAM3

Terms in Intercellular Adhesion Molecule-3 category



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